By F Benedetti; Christoph Stein; et al

ISBN-10: 3540338225

ISBN-13: 9783540338222

ISBN-10: 3540338233

ISBN-13: 9783540338239

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C-Terminal Tail . . . . . . . Signal Transduction . . . . . . Opioid Tolerance . . . . . . . In Vitro . . . . . . . . . In Vivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Opioid Receptor Ligands and Sites of Action .

Few controlled studies investigating the efficacy and side effects of opioids in these clinical settings are available (Caldwell et al. 1999; Moulin et al. 1996; Peloso et al. 2000; Watson and Babul 1998). At the moment, the maximum duration of opioid treatment investigated in a double-blind placebo-controlled study is 9 weeks (Moulin et al. 1996). Most trials found a reduction in subjective pain scores, but only one study examined in detail much more important parameters such as psychosocial features, quality of life, drug dependence, and functional status (Moulin et al.

In: Kumazawa T, Kruger L, Mizumura K (eds) The polymodal receptor: a gateway to pathological pain. Progress in brain research, vol 113. Elsevier Science, Amsterdam, pp 161–184 Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36:57–68 Kendall NA (1999) Psychological approaches to the prevention of chronic pain: the low back paradigm. Baillieres Best Pract Res Clin Rheumatol 13:545–554 Khasabov SG, Rogers SD, Ghilardi JR, Pertes CM, Mantyh PW, Simone DA (2002) Spinal neurons that possess the substance P receptor are required for the development of central sensitization.

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Analgesia by F Benedetti; Christoph Stein; et al


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