By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

ISBN-10: 070203519X

ISBN-13: 9780702035197

Background Lesions in Laboratory Animals can be a useful relief to pathologists wanting to acknowledge heritage and incidental lesions whereas interpreting slides taken from laboratory animals in acute and protracted toxicity reviews, or whereas studying unique species in a diagnostic laboratory. It provides transparent descriptions and illustrations of the vast majority of historical past lesions prone to be encountered. a few of the lesions coated are strange and will be incorrect for treatment-related findings in preclinical toxicity studies.

The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all of the laboratory animal species coated and who've released commonly in those areas.

  • over six hundred high-definition, most reliable colour images of heritage lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
  • a separate bankruptcy on lesions within the reproductive platforms of all laboratory animals written by means of Dr Dianne Creasy, an international professional on testicular lesions in laboratory animals
  • a bankruptcy on universal artifacts that could be saw in histological glass slides
  • extensive references to every lesion described
  • aging lesions encountered in all laboratory animal species, relatively in rats in mice that are used for carcinogenicity studies

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Extra resources for Background Lesions in Laboratory Animals. A Color Atlas

Sample text

400. 91 Hyperplasia of rat pelvic urothelium with vascular ectasia. ×200. 92 Mineralization of the transitional epithelium of the pelvis of the rat kidney. ×200. 30 BACKGROUND LESIONS IN LABORATORY ANIMALS single type of cell may occur in the rat pituitary (Fig. 97). The focus is slightly delineated from the normal cell population with little or no evidence of compression. The vascular channels within the region are normal in comparison to the pattern seen in adenomas, in which they are often ectatic (Fig.

200. 134 Harderianization of the lacrimal gland of the rat. ×200. 137 Retinal rosettes in the eye of the rat. ×100. 135 Acinar atrophy and inflammation in lacrimal gland of the rat. ×200. 141 Lenticular autolysis which is similar to lenticular degeneration in the rat eye. ×100. 36 BACKGROUND LESIONS IN LABORATORY ANIMALS Auricular chondritis (Fig. 142) is a lesion noted in the ears of older rats which consists of cartilage degeneration, fibrosis and inflammatory cell infiltration. , 1962. Sebaceous glands in the gingiva of the rat.

Vacuolation is occasionally observed in the large neurones of aged rats as a background change (McMartin et al 1997). Artifactual vacuolation in the brain is common and should be distinguished from vacuolation associated with pathology. The lesion may occur unilaterally or bilaterally. 131 Bizarre mitotic figures present in the neonatal rat brain at day 12. ×100. 127 Nucleus circularis in the cerebrum of a neonatal rat. ×200. 132 Ectopic granule cells in the neonatal rat brain. ×100. 128 Foci of neuroblasts in the neonatal rat brain.

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Background Lesions in Laboratory Animals. A Color Atlas by Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

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