By Pavel A. Pevzner

ISBN-10: 0262161974

ISBN-13: 9780262161978

ISBN-10: 1423733339

ISBN-13: 9781423733331

In a single of the 1st significant texts within the rising box of computational molecular biology, Pavel Pevzner covers a huge variety of algorithmic and combinatorial subject matters and exhibits how they're attached to molecular biology and to biotechnology. The publication has a considerable "computational biology with no formulation" part that offers the organic and computational principles in a comparatively easy demeanour. This makes the fabric available to computing device scientists with out organic education, in addition to to biologists with constrained historical past in computing device technology.

Computational Molecular Biology sequence machine technological know-how and arithmetic are remodeling molecular biology from an informational to a computational technological know-how. Drawing on computational, statistical, experimental, and technological equipment, the hot self-discipline of computational molecular biology is dramatically expanding the invention of latest applied sciences and instruments for molecular biology. the recent MIT Press Computational Molecular Biology sequence presents a different venue for the speedy ebook of monographs, textbooks, edited collections, reference works, and lecture notes of the best quality.

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Extra info for Computational Molecular Biology. An Algorithmic Approach

Sample text

Clones 1, 3, and 4 in this ordering are chimeric. , 1995 [3] and Mayraz and Shamir, 1999 [234] designed algorithms that work well in the presence of hybridization errors. A placement is an assignment of an interval on the line [0, N] to each clone (the line [0, N] corresponds to the entire DNA molecule). An interleaving is a specification of the linear ordering of the 2n endpoints of these n intervals. An interleaving may be viewed as an equivalence class of placements with a common topological structure.

The right overlap of equals 13 - 9 = 4. For an interval I = [i, j] with I < i < j < I, define I c — {Cfc : ^ < ^ < i } as the set of fragments between Cj and Cj. 4). 3. 5: Multiple DDP solutions that cannot be transformed into one another by cassette exchange. be the starting positions of the leftmost fragments of I A and IB respectively. The left overlap of (J^, IB) is the distance TUA — ms- The right overlap of (IA, IB) is defined similarly, by substituting the words "ending" and "rightmost" for the words "starting" and "leftmost" in the definition above.

The following fingerprints have been used in many mapping projects. • Restriction maps. The restriction map of a clone provides an ordered list of restriction fragments. If two clones have restrictions maps that share several consecutive fragments, they are likely to overlap. , 1987 [204] constructed a physical map of the E. coli genome. • Restriction fragment sizes. Restriction fragment sizes are obtained by cutting a clone with a restriction enzyme and measuring the sizes of the resulting fragments.

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Computational Molecular Biology. An Algorithmic Approach by Pavel A. Pevzner


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