By Asfar Azmi

ISBN-10: 0128035056

ISBN-13: 9780128035054

ISBN-10: 0128035412

ISBN-13: 9780128035412

Conquering RAS: From Biology to melanoma Therapy offers introductory wisdom on how smooth RAS biology is taking form in mild of more recent technological improvement. every one bankruptcy is written in a fashion that emphasizes simplicity and clarity for either new investigators and verified researchers. whereas RAS biology has been intensively studied for greater than 3 many years, we're but to work out any potent therapeutics which could intrude within the signaling cascade regulated by way of this grasp oncogene.

The ebook covers subject matters starting from easy RAS biology, to translational biology and drug discovery purposes. those issues should be beautiful to uncomplicated researchers operating in labs who search deeper realizing of the trendy recommendations in RAS study. at the different facet, the oncologist on the patient’s bedside will locate the booklet precious as they generally face the daunting activity of treating sufferers that predominantly have a sickness pushed through oncogenic KRAS.

  • Brings jointly huge ranging issues in RAS easy and translational biology for the medical and scientific communities
  • Showcases fresh developments in RAS examine below one complete volume
  • Includes movies, colour illustrations, and significant web site hyperlinks to facilitate a transparent realizing of RAS in melanoma research

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Extra info for Conquering RAS. From Biology to Cancer Therapy

Example text

39] Seidel C, Schagdarsurengin U, Blumke K, Wurl P, Pfeifer GP, Hauptmann S, et al. Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol Carcinog 2007;46:865–71. [40] Grawenda AM, O’Neill E. Clinical utility of RASSF1A methylation in human malignancies. Br J Cancer 2015;113:372–81. [41] Vlahov N, Scrace S, Soto MS, Grawenda AM, Bradley L, Pankova D, et al. Alternate RASSF1 transcripts control SRC activity, E-cadherin contacts, and YAP-mediated invasion. Curr Biol 2015;25:3019–34.

Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)-ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration. Cell Signal 2014;26:343–51. [77] Hilton HN, Stanford PM, Harris J, Oakes SR, Kaplan W, Daly RJ, et al. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta 2008;1783:383–93. [78] Heidary Arash E, Song KM, Song S, Shiban A, Attisano L. Arhgef7 promotes activation of the Hippo pathway core kinase Lats.

3 Activation of the ERBB family of receptors by growth factors activates Ras MAPK signaling (green arrows). The Ras effector Raf inactivates MST1 and MST2 by preventing dimerization. Ras can also be activated by G-protein–coupled receptors receptor. GPCR activation of the heterotrimeric G-proteins Ga, G11, and Gq have a strong stimulation of Rho activity, which inhibits MST and LATS via modulating actin dynamics. In addition, Rho mediates inhibition of cAMP-dependent protein kinase A (PKA). In contrast, GPCR activation of Gs results in PKA activation and repression of LATS, thereby facilitating YAP nuclear localization.

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Conquering RAS. From Biology to Cancer Therapy by Asfar Azmi

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