By E. Díaz-Rubio, H.-J. Schmoll

ISBN-10: 3805580479

ISBN-13: 9783805580472

Complement factor: Oncology 2005, Vol. sixty nine, Suppl. three

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Additional info for Critical Role of Anti-angiogenesis And Vegf Inhibition in Colorectal Cancer (Supplement Issue: Oncology 2005)

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Combining Bevacizumab with 5-FU-Based Regimens – Current Status Capecitabine in Metastatic CRC Another drug that has shown clinical benefit in metastatic CRC is capecitabine [26]. Capecitabine is a tumorselective oral fluoropyrimidine generating 5-FU prefer- As studies have shown that none of the currently used regimens have demonstrated clear superiority over other regimens [25], it is likely that bevacizumab will be combined with many different chemotherapy regimens. Initial studies have examined the benefits of combining bevacizumab with 5-FU and IFL, and ongoing studies are examining combinations with oxaliplatin and capecitabine.

16 Chen HX: Expanding the clinical development of bevacizumab. Oncologist 2004; 9(suppl 1): 27–35. 17 Giantonio BJ, Catalano PJ, Meropol NJ, O’Dwyer PJ, Mitchell EP, Alberts SR, Schwartz MA, Benson AB: High-dose bevacizumab in combination with FOLFOX4 improves survival in patients with previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200. J Clin Oncol 2005; 23(suppl):1s (abstract 2). 18 Hochster HS, Welles L, Hart L, Ramanathan RK, Hainsworth J, Jirau-Lucca F, Shpilsky A, Griffing S, Mass R, Emanuel D: Safety and efficacy of bevacizumab (Bev) when added to oxaliplatin/fluoropyrimidine (O/F) regimens as first-line treatment of metastatic colorectal cancer (mCRC): TREE 1 & 2 Studies.

Clinical trials are also investigating bevacizumab in combination with other biological therapies, including cetuximab (Erbitux®), which is approved for use in patients with metastatic CRC who have failed prior irinotecan-containing chemotherapy. Phase II trials of bevacizumab in combination with cetuximab and irinotecan in bevacizumab-naïve (trial BOND-2) and bevacizumabrefractory (trial BOND-3), pretreated patients are currently underway [46]. BOND-2 has reported promising data indicating that bevacizumab improves response rates and PFS [46].

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Critical Role of Anti-angiogenesis And Vegf Inhibition in Colorectal Cancer (Supplement Issue: Oncology 2005) by E. Díaz-Rubio, H.-J. Schmoll


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