By Wei Yang (Eds.)
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Additional info for DNA Repair and Replication
As discussed above, the function of TDG is critical for removal of T:G mismatches arising via deamination of 5-methylcytosine. , 2002). Sumoylation increases the turnover rate of TDG while suppressing the activating effect of APE1 by reducing the afﬁnity of TDG for DNA. This type of regulation is thus far unique to TDG among DNA glycosylase. , 2002). This interaction stimulates transcription in cells and leads to acetylation of TDG. The signiﬁcance of increased transcription may be that the loosened chromatin structure of a transcriptionally active region allows DNA repair proteins easier access to the damaged site.
2001). , 2003). PARP-1 binds to single-strand nicks in DNA (Benjamin and Gill, 1980) and is believed to play a role in damage repair by scanning the genome for these nicks. , 2001). The role of PARP in BER is discussed further later. , 2004). FEN-1 binds to a kinked structure of the DNA duplex made possible by the discontinuity of the nicked strand. The authors use the structure of a FEN1 peptide bound to PCNA to propose a model of how PCNA orients FEN-1 for interaction with DNA at a replication site (Fig.
Natl. Acad. Sci. USA 87, 4193–4197. , Ueng, L. , Kohn, K. , and Pommier, Y. (1997). Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I. J. Biol. Chem. 272, 7792–7796. , Beard, W. , Chyan, J. , Maciejewski, M. , Mullen, G. , and Wilson, S. H. (1998). Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 50 -deoxyribose phosphate lyase activities.
DNA Repair and Replication by Wei Yang (Eds.)