By Walter Doerfler, Petra Böhm
This ebook provides epigenetics examine as a brand new approach of genetics. themes diversity from uncomplicated epigenetics mechanisms to improvement of cells and organisms and the organic foundation of illnesses. furthermore the e-book specializes in immunology and the function of viruses in epigenetics. The final a part of the e-book highlights proteins and peptides as epigenetic modulators.
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Extra info for Epigenetics - A Different Way of Looking at Genetics
2014). The imprinted Kcnq1 domain on mouse chromosome 7 is controlled by a maternally methylated ICR. This ICR is located in an intron of the Kcnq1 gene, one of the imprinted genes of the 750-kb Kcnq1 domain. Long-range chromatin interactions at this domain require an lncRNA called Kcnq1ot1, which is expressed from the unmethylated copy of the ICR. Recent research indicates that the Kcnq1ot1 lncRNA stabilizes particular long-distance chromatin interactions between the ICR and the Kcnq1 gene promoter.
2012). These conceptually interesting studies have raised the question as to whether some of the imprinted ncRNAs could be involved in transcriptional activation as well. At the Dlk1-Dio3 domain, the paternally methylated ICR activates imprinted gene expression on the maternal chromosome in the early embryo. Particularly, targeted deletion of this ICR region on the maternal chromosome gave rise to a complete loss of expression of all the maternally transcribed ncRNAs, including the lncRNA Gtl2/Meg3 (Lin et al.
This lncRNA could therefore contribute to PRC2-mediated repression of protein-coding genes in cis on the maternal chromosome, which would agree with its developmental expression pattern (da Rocha et al. 2007). Additionally, Gtl2 lncRNA could possibly also have effects in trans given that its perturbed expression in iPS cells affected the expression of genes elsewhere in the genome as well, although it is not excluded that these effects are indirect (Kaneko et al. 2014). Gene-targeting studies in the mouse have disrupted Gtl2 expression to directly test the in vivo function of this lncRNA (Zhou et al.
Epigenetics - A Different Way of Looking at Genetics by Walter Doerfler, Petra Böhm