By Hans Kuhn
In an try to comprehend the beginning of residing structures we stumble upon the next difficulties: a) How do we conceive the beginning of the 1st self-reproducing types, and through what stimuli may possibly begin a continuing bring up within the complexity of such types? b) How can a translation equipment for genetic info boost? One can't think that such an gear for the synthesis of en zymes can functionality on my own with no the interference of enzymes them selves, which, notwithstanding, may perhaps basically develop into to be had after the construc tion of the gear itself. c) What stimulus mechanism is possible, that ends up in the department of the genetic gear right into a duplication procedure and an enzyme synthesis procedure? the most challenge for this reason isn't the look for easy theoretical thoughts. it isn't a question that are responded through a particular test. One should still really discover the significant probabilities of how molecules mix to supply an increasing number of advanced func tional devices. In attempting to clear up the puzzle of the way the genetic equipment is progressively equipped up as a fancy mixture of molecules you'll be able to draw up particular Denkmodels.
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Additional info for Evolution selbstorganisierender chemischer Systeme. Zur Leistungsfähigkeit homogener Übergangsmetall-Katalysatoren
Ursprung der Chiralitiit durch Zufallsereignis Ein Baustein der N ukleotide, die Ribose, ist chiral: Da bei der Polymerisation nur dann ein replikationsfahiger Strang entsteht, wenn der Matrizenstrang mit dem neusynthetisierten Strang eine praktisch fehlerfreie Doppelhelix bilden kann, muB in allen monomeren Bausteinen die gleiche chirale Form eingebaut sein (entweder iiberall d oder iiberall I-Ribose). Andere Polymermolekiile waren wegen der fehlenden Kooperativitat nicht replikationsfahig. Die Tatsache, daB in den heute bekannten Nukleinsauren nur die d-Form der Ribose vorkommt, beruht nach dem Modell auf dem Zufall, daB sich zuerst ein reproduktionsfahiges System aus d-Ribose durchsetzen konnte.
We shall describe a function (knowledge K) which establishes a standard of value for genetic information, which increases - under specific restrictions - during the evolution process. The evolution leads repeatedly to barriers due to the fact that the information quantity transferred from one generation to the next is limited by the rate of errors during replication. In due time each one of these barriers is overcome by means of a principal change in the organizational system, decreasing the error rate of replication.
Dekker, J. Mol. Evolution 2, 137 (1973); Nature New Biology 241, 72 (1973). 21 E. Harbers, Nucleinsauren, Thieme Verlag, Stuttgart, 1969. 22 S. H. : Science 179, 285 (1973). 23 D. R. Kearns and R. G. Shulman, Accounts of Chem. Res. 7, 33 (1974). 24 J. D. Bernal, The Origin of Life, World Publishing Co. New York 1967. 25 A. G. Cairns-Smith, The Origin of Life and the Nature of the Primitive Gene, J. Theor, BioI. 10,53 (1966). J. 278, Pergamon Press, London 1958. 1 Summary In an attempt to understand the origin of living systems we encounter the following problems: a) How can we conceive the origin of the first self-reproducing forms, and by means of what stimuli could commence a constant increase in the complexity of such forms?
Evolution selbstorganisierender chemischer Systeme. Zur Leistungsfähigkeit homogener Übergangsmetall-Katalysatoren by Hans Kuhn