By David A.D. Parry, John M. Squire
Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the 1st of a three-part sequence on Fibrous Proteins. The books are in line with a really winning workshop in Alpbach, Austria at the common subject of Fibrous Proteins that gave upward push to the award successful factor of magazine of Structural Biology. half II will comprise an intensive dialogue of Molecular automobiles and Muscle, half III on Amyloids, Prions and Beta Proteins. Advances in Protein Chemistry is on the market on-line on ScienceDirect - full-text on-line of volumes fifty three onwards. *Reveals new structural and sensible facets of fibrous proteins*Based on Fibrous Protein workshop in Alpbach, Austria that gave upward push to 2003 Nobel Prize winners in Chemistry
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Additional resources for Fibrous Proteins: Coiled-Coils, Collagen and Elastomers
In a two-stranded, parallel coiled coil, the CÀC bond of a residue in position a is parallel to the peptide bond facing it in the opposing helix; in position d, it is perpendicular. Thus, the distance between the C carbons of core residues in position a (a layers) is large, favoring -branched side-chains for tight packing (Ile, Val, Thr), whereas it is small for core residues in position d (d layers), favoring residues unbranched at C (Leu, Ala). This situation is exactly reversed in parallel, four-stranded coiled coils.
J. Mol. Biol. 231, 521–530. McLachlan, A. D. (1978). Coiled coil formation and sequence regularities in the helical regions of -keratin. J. Mol. Biol. 124, 297–304. McLachlan, A. , and Karn, J. (1983). Periodic features in the amino acid sequence of nematode myosin rod. J. Mol. Biol. 164, 605–626. McLachlan, A. , and Stewart, M. (1976). The 14-fold periodicity in -tropomyosin and the interaction with actin. J. Mol. Biol. 103, 271–298. 34 PARRY McLachlan, A. , and Stewart, M. (1982). Periodic charge distribution in the intermediate filament proteins desmin and vimentin.
C. Discontinuities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . D. Coiled Coils that Deviate Globally from the Standard Model . . . . . .. . . III. Structural Determinants of Folding and Stability . . . . . . . . . . . . . . . . . . A. Number of Helices . . . . . .. . . . . . . . . . . . .. . . . . . . . . . . . .. . . B. Orientation and Oligomer Specificity . . . . . .
Fibrous Proteins: Coiled-Coils, Collagen and Elastomers by David A.D. Parry, John M. Squire