By Noah Hardy, Eric Westhof
This complaints quantity explores the pathways and mechanisms through which constituent residues have interaction and fold to yield local organic macromolecules (catalytic RNA and practical proteins), how ribosomes and different macromolecular complexes self-assemble, and appropriate energetics issues.
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Additional info for Folding and Self-Assembly of Biological Macromolecules: Proceedings of the Deuxiemes Entretiens de Bures, Institut Des Hautes Etudes Scientifiques, Bures-sur-Yvette, France, 27 November-1 December 2001
7 million lines of paired amino acid sequences. How do we explain this? Again, I do not know for certain. But you can go back and look at the codon for tryptophan. It is U-G-G in the standard code. Suppose I have only a small amount of time to diverge; suppose I only have time to change one of the three bases in the U-G-G codon for tryptophan. I can make AGG or CGG or GGG, or I can make UAG or UCG or UUG, and so on. It turns out that the way the code is structured, none of the codons that arise from a single nucleotide replacement in the tryptophan codon code for phenylalanine; two of them code for arginine, and two for cysteine.
Response: OK, what you're looking for is the red DNA [in Figure 5], which is the analyte, and the readout is going to be glowing solid supports; so at some point you've got glowing solution - this is all present in solution. At some point you're going to recover the solid support and see if is glowing. The green molecules glow - but in any case they give off light from the support only if they're attached to the solid support. The theory is that the specificity of Watson-Crick base-pairing, A-TG-C, will guarantee that the only way the green molecules will stick to the support is if there is something in between to bind them.
In some cases these studies include the resurrection of ancient forms. Our goal is analysis of the global proteome. With scientists at EraGen Biosciences in Madison Wisconsin, we have assembled what is called the Master Catalog, which is based on the fact that after all the genomes of all the organisms on Earth have been sequenced, there are only going to be about 100,000 families of proteins. Every one of them tells a story that we are working through one at a time. If anyone would like to help, please let me know.
Folding and Self-Assembly of Biological Macromolecules: Proceedings of the Deuxiemes Entretiens de Bures, Institut Des Hautes Etudes Scientifiques, Bures-sur-Yvette, France, 27 November-1 December 2001 by Noah Hardy, Eric Westhof