By Nicholas H. Acheson

ISBN-10: 0470900598

ISBN-13: 9780470900598

This new, absolutely revised moment variation of Fundamentals of Molecular Virology is designed for collage scholars studying approximately virology on the undergraduate or graduate point. Chapters disguise lots of the significant virus households, emphasizing the original positive factors of every virus family members. those chapters are designed to inform tales concerning the viruses lined, and comprise info on discovery, illnesses and pathogenesis, virus constitution, steps in viral replication, and interplay with mobile signaling pathways. This method portrays the “personality” of every virus, assisting scholars to profit the cloth and to accumulate their wisdom of virology, beginning with smaller and less complicated viruses and continuing to extra complicated viruses.

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1 Schematic diagram of virus particles. Illustrated are the two most common capsid morphologies: a roughly spherical shell (left) and a tubular rod (right). Some virus particles have an envelope (left) and some do not (right). Nucleic acid genomes are shown as black curved lines, capsid proteins as green spheres, and envelope proteins as orange knobbed spikes. indd 3 16/05/11 7:46 PM 4 CHAPTER 1 Introduction to Virology messenger RNAs, which in turn synthesize viral proteins using the enzyme systems, energy, ribosomes, and molecular building blocks that are present in the cell.

6. Late viral proteins package viral genomes and assemble virions Structural proteins used to package viral genomes and to assemble the capsid are usually the most abundant viral proteins made in an infected cell. 1). Larger and more complex viruses may have numerous capsid proteins, and some viruses make scaffolding proteins that are involved in virion assembly but are subsequently discarded and do not form part of the mature virion. Many bacteriophages have both a polygonal head that contains the genome and a tubular tail involved in attachment to the cell and delivery of the genome.

The virion binds to cell surface receptors. 2. The virion or viral genome enters the cell; the viral genome is uncoated. 3. Early viral genes are expressed (Baltimore classification scheme). indd 2 16/05/11 7:46 PM The Nature of Viruses 4. 5. 6. 7. 3 Early viral proteins direct replication of the viral genome. Late viral genes are expressed from newly replicated viral genomes. Late viral proteins package genomes and assemble progeny virus particles. Virions are released from the host cell. THE NATURE OF VIRUSES Viruses consist of a nucleic acid genome packaged in a protein coat Viruses are the smallest and simplest forms of life on Earth.

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Fundamentals of molecular virology by Nicholas H. Acheson


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