By Engelbert Buxbaum

ISBN-10: 0387263527

ISBN-13: 9780387263526

Textbook for classes at either graduate and undergraduate point. additionally for comparable classes in biochemistry, biochemistry lab, and techniques. includes accomplished analytical description of constitution, biophysics, and serve as of proteins. additionally summarizes the options used to signify protein and protein interactions.

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Additional resources for Fundamentals of Protein Structure and Function

Example text

The protein structures presented in this book were created with DeepView from data files obtained from OCA. 4 Quaternary structure Quaternary structure describes how several polypeptide chains come together to form a single functional protein. Like tertiary structure it is determined by ionic and hydrophobic interactions between amino acid R-groups. Many proteins consist of several subunits. Depending on the number of subunits, we speak of monomers, dimers, trimers and so on. Depending on whether these subunits are identical or not, we put homo- or hetero- in front.

E) Multi-domain proteins Folds consisting of two or more domains belonging to different classes f) Membrane and cell surface proteins (excluding proteins from the immune system). Usually the transmembrane domains are α-helical, but β-barrels may also occur. g) Small proteins Usually dominated by metal ligand, haeme, and/or disulphide bridges h) coiled coil proteins α-helices wound around each other. 7. Examples for α, β, α/β and α + β protein structures. There are two images for each protein (right and left eye view) to achieve a stereo effect.

A comparison of structures determined by the two methods shows fortunately that they are fairly similar, giving us faith in both. Computer predictions The biggest problem for the determination of protein structure is the vast amount of highly purified protein required (≈ 100 mg) for any of the above 22 2 Protein structure methods. Many proteins of particular biological interest occur in very small amounts in our body. In the last 20 years the sequences of many proteins have been determined by DNA sequencing (an almost complete sequence of the human genome was published in 2001 [16, 17, 78]).

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Fundamentals of Protein Structure and Function by Engelbert Buxbaum

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