By Julio Collado-Vides, Ralf Hofestädt

ISBN-10: 026203297X

ISBN-13: 9780262032971

ISBN-10: 0585436916

ISBN-13: 9780585436913

As intriguing because the new box of genomics is, it has no longer but produced a uncomplicated conceptual switch in biology. the elemental difficulties stay: the starting place of lifestyles, mobile association, the pathways of differentiation, getting older, and the molecular and mobile features of the mind. What has happened is an explosion of molecular details got through genomic sequences, that allows you to quickly be through exhaustive catalogs of protein interactions and protein functionality. This wealth of knowledge will be analyzed and manipulated basically with the aid of pcs. The quickly increasing function of pcs in biology may well bring in a profound conceptual swap in how we learn dwelling platforms within the laboratory. This ebook makes a speciality of present computational ways to knowing the complicated networks of metabolic and gene regulatory functions of the cellphone. The individuals glance way past the cutting-edge in computational biology to count on what organic learn should be like in a post-genomic international.

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2000) based on analysis of all pairwise similarities among the protein sequences. , 2000). uk/clustr/), the database of clusters of SWISS-PROT and TrEMBL proteins developed at EBI, will be discussed in some detail in this chapter. It offers an automatic classification of SWISS-PROTþTrEMBL (SPTR) proteins into groups of related proteins. The clustering is based on analysis of all pairwise comparisons between protein sequences. Analysis has been carried out for different levels of protein similarity, yielding a hierarchical organization of clusters.

Et al. (2000). Integrating functional genomic information into the Saccharomyces Genome Database. Nucleic Acids Res. 28: 77–80. , Eddy, S. , Howe, K. , and Sonnhammer, E. L. L. (2000). The Pfam Protein Families Database. Nucleic Acids Res. 28: 263–266. Berman, H. , Bhat, T. , Shindyalov, I. , and Bourne, P. E. (2000). The Protein Data Bank. Nucleic Acids Res. 28: 235–242. Blake, J. , Eppig, J. , Richardson, J. , Davisson, M. , and the Mouse Genome Database Group. (2000). The Mouse Genome Database (MGD): Expanding genetic and genomic resources for the laboratory mouse.

Lewis, A. , Mabey, J. , Selley, J. , and Wright, W. (2000). PRINTS-S: The database formerly known as PRINTS. Nucleic Acids Res. 28: 225–227. , and Apweiler, R. (2000). The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res. 28: 45–48. Ball, C. , Dwight, S. , Harris, M. , Scafe, C. , et al. (2000). Integrating functional genomic information into the Saccharomyces Genome Database. Nucleic Acids Res. 28: 77–80. , Eddy, S. , Howe, K. , and Sonnhammer, E. L. L.

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Gene Regulation and Metabolism Post Genomic Computational Approaches by Julio Collado-Vides, Ralf Hofestädt

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