By Mark A Stacy
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Extra resources for Handbook of dystonia
In Norway (13) the prevalence of late-onset dystonia was higher in subjects of European descent (283 per million) than among ﬁrst-generation immigrants of Asian and African descent (34 per million). Several studies have demonstrated unequivocally that primary dystonia can aggregate in families (19,21,26,27), and family history of dystonia is considered the most important of the known risk factors for primary dystonia. Although the presence of more than one affected member in the same family nucleus may be because of chance or because of shared environmental factors, a genetic contribution seems highly likely.
A case-control study of idiopathic torsion dystonia. Mov Disord 1991; 6:304–309. 38. Saunders Pullman R, Shriberg J, Shanker V, Bressman SB. Penetrance and expression of dystonia genes. In: Fahn S, Hallett MK, DeLong MR, eds. Dystonia 4. Advances in Neurology. Vol. 94. Philadelphia: Lippincott, Williams and Wilkins, 2004:121–125. 39. Defazio G, Berardelli A, Abbruzzese G, et al. Possible risk factors for primary adult-onset distonia, a case-control investigation by the Italian Movement Disorders Study Group.
32. Kramer PL, Heiman GA, Gasser T, et al. The DYT1 gene on 9q34 is responsible for most cases of early limb-onset idiopathic torsion dystonia in non-Jews. Am J Hum Genet 1994; 55:468–475. 33. Defazio G, Martino D, Aniello MS, et al. A family study on primary blepharospasm. J Neurol Neurosurg Psychiatry 2006; 77:252–254. 34. Fletcher NA, Harding AE, Marsden CD. Intrafamilial correlation in idiopathic torsion dystonia. Mov Disord 1991; 6:310–314. 35. Eldridge R, Ince SE, Chernow B, Milstien S, Lake CR.
Handbook of dystonia by Mark A Stacy