By Wallace B. Morrison
This consultant for the analysis and remedy of lymphomas in canine and cats is geared up into components: noncutaneous and cutaneous lymphomas. supporting the practitioner in choosing lymphomas that may be handled and defining the result that may be anticipated, the sensible consultant contains specified dialogue in regards to the overview tools used to assist prognosis lymphomas. those contain histological class, immunophenotyping, AgNOR evaluation, and scientific laboratory findings, in addition to how those effects be certain the strategy of remedy. Lymphoma in canines and Cats comprises specific guide for using general chemotherapeutic protocols and radiation remedy in addition to assorted treatments comparable to rescue and dietary remedy. Tables summarize suggested diagnostic work-ups, scientific staging and steered therapy protocols, while 25 colour images and 20 charts make it a good quickly reference resource that each clinician must have on hand.
Published through Teton New Media within the united states and dispensed by CRC Press outside of North the USA.
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Additional info for Lymphoma in Dogs and Cats
Courtesy of Dr. qxd 12/22/04 1:15 PM Page 31 homing of malignant T-lymphocytes to the mucosal epithelium of the intestinal tract that is characteristic of this disorder. The clinical signs and histologic findings in epitheliotrophic alimentary lymphoma will vary widely. 49 In the other report of epithelioptrophic lymphoma, 8/10 cats had involvement with small, but malignant lymphocytes, and the other 2/10 cats had involvement with intermediate sized malignant lymphocytes. Immunophenotyping of the cats in this study showed that all 10 cats had T-cell disease.
Hypereosinophilic syndrome is characterized by bone marrow hyperplasia of eosinophilic precursors and multiple organ infiltration by mature eosinophils. 78 Neither hypereosinophilic syndrome nor eosinophilic leukemia appears to be associated with FeLV infection. Pulmonary eosinophilia may be seen in cats with hypersensitivity disorders that affect the lung. Pulmonary eosinophilia may be triggered by a variety of inhaled environmental stimulants, lung parasites, migrating larvae, and heartworm. 79 However, eosinophilia is not a reliable hallmark of lymphoma in cats.
See Table 2 for additional information on mAb detection of CD antigen expression for cell phenotype identification. 36 Interpretation Expressed by cortical thymocytes, but not by mature T cells. CD1 is useful in identifying histiocytic proliferations Expressed only on the surface of mature T cells and thymocytes Expressed by B lymphocytes Expressed by T helper cells Usually expressed by T cytotoxic cells and some natural killer (NK) cells Expressed by mature B cells One isoform known as CD45RA is expressed by all B cells and is detectable in formalin fixed tissues Expressed by stem and progenitor cells of lymphocytes and other cells.
Lymphoma in Dogs and Cats by Wallace B. Morrison