By Eric Holtzman (auth.)

ISBN-10: 0306431262

ISBN-13: 9780306431265

ISBN-10: 1489925406

ISBN-13: 9781489925404

In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer­ Verlag, Vienna) that was once meant as an updated, complete survey. no matter what good fortune i'll have accomplished then in pleasing that goal, even the trouble now will be foolhardy. The literature has grown so speedily some time past decade that I definitely couldn't even learn the entire crucial papers, not to mention comprehend and examine them. My aim right here, as a result, is just to introduce the foremost beneficial properties of lysosomes at a degree i'm hoping can be valuable either to I;ldvanced scholars and to researchers attracted to acquiring a wide historical past. this can be based on the layout of the mobile Organelles sequence: the sequence is extra a collection of complicated texts than of evaluate monographs. This layout incorporates with it the choice to not help every one element by means of refer­ ences to the unique literature. I express regret for the injustice keen on this kind of determination yet believe that during any occasion it might be impossibly unwieldy to quote, correctly and in a balanced demeanour, the contributions of the huge community of researchers chargeable for the data upon which I draw.

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B) Light micrograph showing reactive lysosomes scattered throughout the cell body of a neuron in a mouse ganglion. The prominent sphere in the center of the cell is a nucleolus within the nucleus; it is seen by virtue of its intrinsic refractility and does not contain heavy reaction product. From Holtzman, E. (1969) In Lysosomes in Biology and Pathology 0. T. Dingle and H. B. ), Vol. 1, North-Holland, Amsterdam, p. 192. x 1000. (c) Electron micrograph of a lysosome from an epinephrine cell of rat adrenal medulla showing sulfatase reaction product as a dense deposit.

B. (1973) Lysosomes: A personal account, in Lysosomes and Storage Diseases (H. G. Hers and F. ), Academic Press, New York, pp. 1-41. , and Dubois, F. (1978) Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient, J. Cell BioI. 78:349364. , and Urech, K. (1979) Vacuoles: The sole compartment of digestive enzymes in yeast (Saccharomyces cerevisiae)? Arch. Microbiol. 123:23-35. Wolff, D. A. (1975) The separation of cells and subcellular particles by colloidal silica density gradient centrifugation, Methods Cell BioI.

Through immunocytochemistry, MBP receptor molecules have been found in presumptive primary lysosomal vesicles like those thought to be primary lysosomes from the considerations already summarized (see also Fig. 5). 2: Figs. 10). But studies of the behavior of the MBP receptors suggest that the compartments in which recently made hydrolases are carried to sites of intracellular digestion are not one-way transport devices, like the granules of leukocytes. Rather, the MBP receptors seem to be reusable membrane-associated "shuttles" associated with membranes that move back and forth between the Golgi apparatus and the sites to which hydrolases are sent.

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Lysosomes by Eric Holtzman (auth.)

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