By Raymond Ruddon
Advances in molecular biology over the past a number of a long time are being progressively utilized to our realizing of the molecular biology of melanoma, and those advances in wisdom are being translated into the scientific perform of oncology. This quantity explores probably the most fascinating contemporary advances in simple learn at the molecular biology of melanoma and the way this data is resulting in advances within the prognosis, therapy, and prevention of cancer.* This sequence offers a discussion board for dialogue of latest discoveries, methods, and ideas * Contributions from top students and specialists * Reference advisor for researchers all for molecular biology and similar fields
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Extra resources for Molecular Biology of Cancer: Translation to the Clinic
How can failures be avoided or at least be reduced in our target-based strategies in oncology? The answer is not necessarily immediately obvious. 22 It is also clear from this exercise that selection of tractable pharmacologically validated targets is critical. Extracellular targets, such as receptors, transporters, exoenzymes, cell surface antigens, proteoglycans, and extracellular matrix components, are much more likely to be attractive than intracellular molecular targets. Being fully validated is more important than being new.
The synthetic lethality model can also be extended by replacing a gene deletion with a second drug (Table V). This could obviously be a powerful strategy for identifying novel drug combinations in an unbiased manner (see below). Molecular biology has provided a long list of human oncogenes and tumor suppressors. A number of groups have established isogenic pairs of normal and malignant cell lines suitable for screening of compound libraries or plant, soil, and marine extracts, which are complex mixtures of Natural Products, for agents that selectively inhibit cells with cancer-relevant genetic alterations in a high throughput manner.
8. Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006;312:1171–5. 9. Bottone Jr. FG, Moon Y, Kim JS, Alston-Mills B, Ishibashi M, et al. The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3). Mol Cancer Ther 2005;4:693–703. 10. Schmitt CA. Cellular senescence and cancer treatment. Biochim Biophys Acta 2007;1775:5–20. 11. Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, et al.
Molecular Biology of Cancer: Translation to the Clinic by Raymond Ruddon