By James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick

ISBN-10: 0321762436

ISBN-13: 9780321762436

Now thoroughly updated with the newest learn advances, the Seventh variation of James D. Watson’s vintage e-book, Molecular Biology of the Gene retains the certain personality of past variations that has made it the main usual e-book in molecular biology. Twenty-two concise chapters, co-authored through six hugely individual biologists, supply present, authoritative insurance of an exhilarating, fast-changing discipline. 

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Additional resources for Molecular Biology of the Gene (7th Edition)

Sample text

One obvious hypothesis states that genes can change (mutate) to give rise to new genes (mutant genes). This hypothesis was first seriously tested, beginning in 1908, by the great American biologist Thomas Hunt Morgan and his young collaborators, geneticists Calvin B. Bridges, Hermann J. Muller, and Alfred H. Sturtevant. They worked with the tiny fly Drosophila melanogaster. The first mutant found was a male with white eyes instead of the normal red eyes. The white-eyed variant appeared spontaneously in a a parental generation red & culture bottle of red-eyed flies.

When these experiments were carried to a third (F3) progeny generation, all the F2 peas with recessive traits bred true ( produced progeny with the recessive traits). Those with dominant traits fell into two groups: one third bred true ( produced only progeny with the dominant trait); the remaining two-thirds again produced mixed progeny in a 3:1 ratio of dominant to recessive. Mendel correctly interpreted his results as follows (Fig. 1-1): the various traits are controlled by pairs of factors (which we now call genes), one factor derived from the male parent, the other from the female.

The Mendelian View of the World parental generation 1-3 How Mendel’s second law (independent assortment) operates. In this example, the inheritance of yellow (Y ) and green ( y) seed color is followed together with the inheritance of round (R) and wrinkled (r) seed shapes. The R and Y alleles are dominant over r and y. The genotypes of the various parents and progeny are indicated by letter combinations, and four different phenotypes are distinguished by appropriate shading. FIGURE × rryy RRYY RY gametes ry F1 generation RrYy RY Ry F2 generation gametes Ry rY ry RRYy RrYy Ry RRYY RrYY RrYy ry RrYY RrYy rrYY rrYy gametes rY RRYy RRyy Rryy ry RY RY gametes rY 9 RrYy Rryy rrYy rryy GENE LINKAGE AND CROSSING OVER Mendel’s principle of independent assortment is based on the fact that genes located on different chromosomes behave independently during meiosis.

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Molecular Biology of the Gene (7th Edition) by James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick


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