By Joachim Frank PhD

ISBN-10: 0521194288

ISBN-13: 9780521194280

The idea that of molecular machines in biology has remodeled the clinical box in a profound method. Many crucial approaches that happen within the phone, together with transcription, translation, protein folding, and protein degradation, are all conducted via molecular machines. This quantity specializes in vital molecular machines whose structure is understood and whose useful rules were tested through instruments of biophysical imaging (X-ray crystallography and cryo-electron microscopy) and fluorescence probing (single-molecule FRET). This edited quantity comprises contributions from widespread scientists and researchers who comprehend and feature explored the constitution and features of those machines. This e-book is vital for college students and execs within the scientific box who are looking to examine extra approximately molecular machines.

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Additional resources for Molecular Machines in Biology: Workshop of the Cell

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There is an increasing trend toward the use of multiple platforms, mixing and matching the modules as they have different strengths and weaknesses in the different areas of methodology. , 2009) is a pipeline designed to extend existing software applications and procedures, and provides transparent interconversions between the different file formats and angle conventions used in the various packages. 1. 3a). 3b) are extracted from the micrographs with the aid of automated search algorithms, which normally, however, still require verification by eye.

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Aitken, C. , Flusberg, B. , Turner, S. , et al. 2010. Real-time tRNA transit on single translating ribosomes at codon resolution. Nature, 464, 1012–7. Velankar, S. , Dillingham, M. , Subramanya, H. S. & Wigley, D. B. 1999. Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. Cell, 97, 75–84. , Forkey, J. , Mckinney, S. , Goldman, Y. , et al. 2003. 5-nm localization. Science, 300, 2061–5. Yodh, J. , Stevens, B. , Janscak, P. & Ha, T. 2009. BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation.

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Molecular Machines in Biology: Workshop of the Cell by Joachim Frank PhD

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