By Rajesh Uthamanthil, Peggy Tinkey, Elisa de Stanchina

ISBN-10: 0128040106

ISBN-13: 9780128040102

Patient Derived Tumor Xenograft types: Promise, capability and Practice deals information on tips to behavior PDX modeling and trials, together with tips to be aware of whilst those versions are acceptable to be used, and the way the knowledge might be interpreted in the course of the collection of immunodeficient lines.

In addition, right methodologies appropriate for growing to be varied kind of tumors, acquisition of pathology, genomic and different facts in regards to the tumor, capability pitfalls, and confounding history pathologies that happen in those versions also are integrated, as is a dialogue of the amenities and infrastructure required to function a PDX laboratory.

  • Offers assistance on facts interpretation and regulatory aspects
  • Provides necessary strategies and methods for operating with PDX models
  • Includes sensible instruments and capability pitfalls for top practices
  • Compiles all wisdom of PDX versions learn in a single resource
  • Presents the result of first ever worldwide survey on criteria of PDX improvement and utilization in academia and industry

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Extra info for Patient Derived Tumor Xenograft Models. Promise, Potential and Practice

Sample text

Check your cultures! A list of cross-contaminated or misidentified cell lines. Int J Cancer 2010;127:1–8. Briske-Anderson MJ, Finley JW, Newman SM. The influence of culture time and passage number on the morphological and physiological development of Caco-2 cells. Proc Soc Exp Biol Med 1997;214:248–57. Esquenet M, Swinnen JV, Heyns W, Verhoeven G. LNCaP prostatic adenocarcinoma cells derived from low and high passage numbers display divergent responses not only to androgens but also to retinoids.

Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer 2011;11:135–41. Wilmanns C, Fan D, O’Brian CA, Bucana CD, Fidler IJ. Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer 1992;52:98–104. Zeineldin M, Jensen D, Paranjape SR, et al. Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis.

CONSIDER THE HOST: MOUSE XENOGRAFT MODELS Compared with in vitro models, there are distinct advantages to studies using intact animal hosts. Cells grown in monoculture are typically exposed to a relatively homogeneous environment in liquid media unaffected by interaction with other cell types and with consistent distribution of oxygen, nutrients, and drugs or treatments. This contrasts with the microenvironment of a tumor in a human patient, where nutrient and oxygen gradients depend on the relative proximity to vasculature, and other direct and paracrine interactions among the tumor, Limitations of Mouse Xenograft Models Chapter | 3 29 stromal elements, immune system, and remote tissues through cytokine and hormone release.

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Patient Derived Tumor Xenograft Models. Promise, Potential and Practice by Rajesh Uthamanthil, Peggy Tinkey, Elisa de Stanchina


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